S5.2 Reactions of enteric and sympathetic ganglia to a brief inflammatory stimulus in the guinea-pig ileum
Clinical investigations indicate that a brief period of severe gastroenteritis can cause a long-lasting complex of functional abnormalities of the gastrointestinal tract, post-inflammatory irritable bowel syndrome (IBS). Post-inflammatory IBS has been modelled in animals in recent years, and in particular hyperexcitability of neurons in enteric and dorsal root ganglia have been investigated. More recently, we have observed increased excitability of sympathetic neurons that innervate the intestine, following inflammation of the distal ileum [1]. In the current study, we have investigated the histological changes and proliferation of eosinophils and T-cells at 3Â h to 56Â days after ileitis that was induced by injection of TNBS (2,4,6-trinitrobenzenesulfonic acid) into the lumen of the dista...MedWorm Supporter Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.
http://www.autneu-journal.com/article/PIIS1566070209001507/abstract?rss=yes
April 27, 2010, 03:23:30 PM