Two years ago I had a blood test which showed I was positive for gliadin antibody, negative for tissue transaminase and positive for Cow's milk allergy. I had obvious sprue, was feeling unwell, digested food poorly and could not tolerate many foods, had several fluid filled joints, chemical sensitivities, itchy skin and rapicly decaying teeth. I went on a gluten and diary free diet and felt much better but still had problems. My phydician thought I might have Celiac Disease but didn't seem to know much about treating it. I read about the disease online and decided to not have the recommended procedures and instead ordered the DNA tests from Enterolab.com. The report said DQ2 B 302 and DQ2 B 602 and that the 302 allele was a main celiac marker and 602 was a Gluten sensitivity marker. This meant that I had inherited a Celiac marker from one parent and a Gluten sensitivity marker from the other parent. This combinitation meant that if I developed Celiac Disease it would be made worse by the presence of the Gluten sensitivity marker.
I have a brother and a great-uncle who developed Type 1 Autoimmune diabetes as young men. Apparently all three of us inherited the DQ2 602 which results in Type 1 Diabetes in men and intestinal gluten related problems in females.
I found a website where I could enter my two markers and see the worldwide occurance of that combination. It was fairly common in Russia and then spread across europe to Belgium and France then the British Isles. Another path led more south to southern europe and to North Africa. There were several western North American amerindian tribes who carried the combination apparently inherited from the early Russian settlers along the Pacific coast. This followed the spread of my mitochondial Haplogroup T2 DNA which originated in Russia about 10,000 years ago and came to me from my Welsh maternal ancestor.
