Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease
Abstract Lymphocytic colitis (LC) is a disease of unknown aetiology. Among other pathogenetic possibilities, an abnormal reaction to
a luminal antigen has been discussed. To clarify this fact, we characterized the inflammatory infiltrate in LC and compared
it with the Th1 response-related coeliac disease (CD). Biopsies from 10 LC and 10 CD patients were analyzed by immunohistochemistry
for detection of T-bet, the master regulator of Th1 response and its antagonist GATA-3 in T cells employing double labellings.
In LC, 10–20% of intraepithelial lymphocytes (IEL) expressed GATA-3 and the remaining T-bet, whereas in CD, all IEL were T-bet-positive.
The T cells in the lamina propria of LC (65–70% CD4+; 30–35% CD8+) showed a mixed expression pattern of T-bet and GATA-3.
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