50 Years Ago in The Journal of Pediatrics: The Present State of Knowledge on the Celiac Syndrome
Frazer AC. J Pediatr 1960;57:262-76. In the early 1960s the term “celiac syndrome†was commonly used to denote the entire spectrum of malabsorptive disorders. As our knowledge has evolved, we now recognize that celiac disease, the most common form of malabsorption, is a specific autoimmune disorder resulting from permanent intolerance to gluten, the main storage protein of wheat and other grains. The disease was once believed to result from toxic or allergic effects induced by a deleterious agent but is now known to be a T-cell–mediated inflammatory disorder characterized by an immune response against gliadin. The role played by genetic factors was suggested in 1960. Now celiac disease is a well-understood HLA-linked multigenic disorder associated with HLA-DQ2 (DOA1*05/DQB1*02) or H...MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.
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