Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
Background:
Coeliac disease is a chronic intestinal inflammatory disorder caused by an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition in faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls.
Results:
IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients t...MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.
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