Transglutaminase 2 Regulates the GTPase-activating Activity of Bcr [Mechanisms Of Signal Transduction]
Transglutaminase 2 (TG2) is a multifunctional protein that has been implicated in numerous pathologies including that of neurodegeneration and celiac disease, but the molecular interactions that mediate its diverse activities are largely unknown. Bcr and the closely related Abr negatively regulate the small G-protein Rac: loss of their combined function in vivo results in increased reactivity of innate immune cells. Bcr and Abr are GTPase-activating proteins that catalyze the hydrolysis of the GTP bound to Rac. However, how the Bcr and Abr GTPase-activating activity is regulated is not precisely understood. We here report a novel mechanism of regulation through direct protein-protein interaction with TG2. TG2 bound to the Rac-binding pocket in the GTPase-activating domains of Bcr and Abr, ...MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.
http://www.medworm.com/index.php?rid=3081817&cid=c_1_59_f&fid=32070&url=http%3A%2F%2Fwww.jbc.org%2Fcgi%2Fcontent%2Fshort%2F284%2F51%2F35645%3Frss%3D1
