No effects of a synonymous variant within the CD59 gene on its protein product in duodenal biopsies of coeliac individuals
A novel rare variant within the CD59 gene was linked with coeliac disease in a family with high incidence of disease. Functional analyses of this variant were performed using complementary DNA analysis and protein analysis in paraffin-embedded duodenal biopsies from affected individuals and controls. No effects on pre-mRNA or size of linear protein were observed, although these results do not exclude the possible effects of this variant on co-translational protein folding. (Source: Tissue Antigens)MedWorm Supporter Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.
http://dx.doi.org/10.1111%2Fj.1399-0039.2009.01317.x
