Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin α4β7-positive T cells in blood
Summary: Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin α4β7, expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin α4β7 pathway is involved in the pathogenesis of chronic intestinal inflammation by recruiting lymphocytes into inflamed gut. We explored the duodenal expression of mucosal addressin cell adhesion molecule 1 and the peripheral T-cell expression of integrin α4β7 in patients with celiac disease. Duodenal biopsies and a peripheral blood sample were collected from 15 celiac patients, before and after 12 months of gluten-free diet, and from 12 control subjects. Treated celiac biopsies were cultured with peptic-tryptic digest of gliadin and/or ... MedWorm Supporter Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.
http://www.humanpathol.com/article/PIIS0046817708005054/abstract?rss=yes
