Temporal trends of hla genotype frequencies of type 1 diabetes patients in sweden from 1986 to 2005 suggest altered risk
Abstract The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1–18-year-old patients with
type 1 diabetes newly diagnosed in 1986–1987 (n = 430), 1996–2000 (n = 342) and in 2003–2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase
chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986–1987 and 37% (127/342) in 1996–2000, but decreased to 19% (33/171) in 2003–2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986–1987 to 7% in 1996–2000 (P = 0.0047) and to 5% in 2003–2005 (P > 0.05). This study in 1–18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change
in HLA risk.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0048-5Authors
Sabina Resic-Lindehammer, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenK. Larsson, Kristianstad Hospital Department of Pediatrics Kristianstad SwedenE. Örtqvist, Astrid Lindgren’s Hospital Department of Pediatrics Solna SwedenA. Carlsson, University Hospital, Lund University Department of Clinical Sciences, Unit of Pediatrics Malmö SwedenE. Cederwall, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenC. M. Cilio, University Hospital, Lund University Department of Clinical Sciences, Cellular Autoimmunity Unit Malmö SwedenS.-A. Ivarsson, University Hospital, Lund University Department of Clinical Sciences, Unit of Pediatrics Malmö SwedenB. A. Jönsson, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenH. E. Larsson, University Hospital, Lund University Department of Clinical Sciences, Unit of Pediatrics Malmö SwedenK. Lynch, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenJ. Neiderud, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenA. Nilsson, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenS. Sjöblad, University Hospital, Lund University Department of Clinical Sciences, Unit of Pediatrics Malmö SwedenÅ. Lernmark, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö Swedenand the Swedish Childhood Diabetes Study Group
Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica)
http://www.springerlink.com/content/1864227686j5694x/
