[Celiac News] Recent advances in refractory coeliac disease: a review.

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Recent advances in refractory coeliac disease: a review.
           

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        Recent advances in refractory coeliac disease: a review.
        Histopathology. 2008 Aug 11;
        Authors:  Ho-Yen C, Chang F, van der Walt J, Mitchell T, Ciclitira P
        Recent advances in refractory coeliac disease: a reviewCoeliac disease (CD) is an immune-mediated disease of the small intestine caused by intolerance to gluten. Removal of gluten from the diet results in a return to normal health for the majority of patients. A significant proportion of patients do not respond to a gluten-free diet and are considered to be suffering from refractory coeliac disease (RCD). Two types of RCD are now recognized: type 1 RCD is characterized by a polyclonal population of intraepithelial lymphocytes (IELs) with a normal immunophenotype, and type 2 RCD shows monoclonal IELs with an aberrant immunoprofile. Patients with RCD have a high risk of complications such as ulcerative jejunitis (UJ) and enteropathy-type T-cell lymphoma (ETTL). RCD2 may represent an early stage in the development of overt lymphoma. The diagnosis of RCD, therefore, has important implications, but remains a challenging area. In this paper we review the latest developments in RCD, including the diagnostic approach and a discussion of the key clinical, histological, immunohistochemical and molecular features of RCD and its complications.
        PMID: 18700844 [PubMed - as supplied by publisher] (Source: Histopathology)
           

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=18700844&dopt=Abstract